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Amicrobe's priority is the prevention and treatment of life-threatening infections.

Amicidins are a new class of antimicrobials designed for direct application to tissues, especially the exposed tissues of surgery and trauma.  Based on A-Blocks technology, Amicidins are long-chain amino acid block copolymers that are broadly antimicrobial against gram-positive and gram-negative bacteria (including antibiotic-resistant strains), as well as yeast. These novel biological therapeutics also bring beneficial physical properties and a high level of safety.

 

Amicidin-α   Surgical Gel and Amicidin-β   Solution, are intended to prevent and treat the life threatening infections of surgery and trauma.*

 

This work is supported by US Army Medical Research & Materiel Command through the Military Burn Research Program under Award No. W81XWH-15-2-0065 and DoD2 by the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program under Award No. W81XWH-16-1-0561. Opinions, interpretations, conclusions and recommendations are those of Amicrobe and are not necessarily endorsed by the Department of Defense. CARB-X support is provided by the Department of Health & Human Services Asst. Secretary for Preparedness & Response (BARDA) and Wellcome Trust through Boston University subaward 4500002454.

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Amicidin-α Surgical Gel

Amicidin-α Surgical Gel is intended primarily for prophylaxis against infection in surgery & trauma.

 

Designed as a "sword and shield," Amicidin-α kills microbes directly and forms an active microbial barrier to prevent further contamination. Amicidin-α forms a deformable ("flowable") hydrogel that can pass through small openings and rapidly re-gel. This property should facilitate entry into tissue recesses, as well as delivery through applicators such as needles, catheters and spray nozzles.

 

Amicidin-α Surgical Gel is in late-stage preclinical development.* Working with surgical and medical colleagues, Amicrobe is designing clinical trials and preparing for meetings with regulatory authorities.

Therapeutics

A-Blocks    = Amino Acid Block Copolymers

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Broad antimicrobial activity and enhanced barrier properties

A-Blocks products are engineered for effectiveness and safety in direct application to exposed tissues. 

Amicidin-β Solution

Amicidin-β Solution is intended primarily for treatment of life-threatening infections.

 

Amicidin-β demonstrates potent, direct microbial killing and enhanced anti-biofilm properties. Amicidin-β possesses surfactant activity that can assist with tissue cleansing and debridement. It will be applied directly to heavily contaminated or overtly infected tissues, including those with foreign bodies and/or established biofilms.

 

Amicidin-β Solution is in late-stage preclinical development.* Working with surgical and medical colleagues, Amicrobe is designing clinical trials and preparing for meetings with regulatory authorities.

Broad antimicrobial activity and enhanced anti-biofilm properties

Joseph S. Solomkin, MD, FACS, FIDSA; Surgeon, Infection Expert

Amicrobe - Chief Medical Officer

University of Cincinnati College of Medicine - Prof. of Surgery Emeritus

"After a long career, dealing with combat injuries in Vietnam, civilian trauma that in some cases rivals consequences of military action, and managing burn and other soft tissue injuries, A-Blocks appear as a promising approach to the prevention and treatment of a range of infections...

 

They address a truly unmet need."

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