TM

Amicidins

Engineered for physical properties & antimicrobial defense

 

In the living world...
 

Nature's physical properties, the part of the living world that’s visible to the naked eye, are provided by biological polymers. Cellulose is used to build plants and trees; chitin -- insects and shellfish; and collagen -- animals and man. These biopolymers give rise to an incredible range of physical structures.

 

Nature's antimicrobial defense is provided by positively charged (cationic) antimicrobials. Found in multicellular organisms from plants to man, these cationic antimicrobials have defended against harmful bacteria and viruses for eons, with limited evidence of resistance. They work locally - at the point of contact - to yield substantial and ongoing protection.


Amicidins™

 

Amicrobe engineers synthetic biologics called Amicidins. Drawing inspiration from nature, they possess both desirable physical properties and potent antimicrobial activityTheir physical properties make them incredibly versatile. Their antimicrobial activity brings protection against bacteria, fungi, and viruses. In addition, like nature's antimicrobials, Amicidins are designed to be fully biodegradable and safe for the environment, leaving nothing behind that wasn’t already there.
 

Synthetic biologics using nature's playbook

Fan 2021.11.08.png

Amicidins' dual mode of action (physical & microbicidal) enables diverse applications across multiple industries.  With simple formulation and fabrication, these synthetic proteins can yield new products or improve existing ones. Possibilities include breakthrough therapeutics, innovative medical devices, gentler veterinary and pet care products, enhanced consumer health products, and even cleaner food and water. Development is currently underway to bring Amicidin-based next-generation products to life for a safer world, beginning with breakthrough therapeutics for surgery and trauma (see Pipeline).
 

 

A single Amicidin can yield multiple distinct products with diverse applications by adding inactive excipients, other active pharmaceutical ingredients, or even cells.

 

Our two lead Amicidins, Amicidin-α and Amicidin-β, are the key ingredients in multiple product candidates for use in preventing and treating the life-threatening infections of surgery and trauma. Amicidin-α is the foundation for Amicidin-α Surgical Gel and Amicidin-α PFC. Amicidin-β is the foundation for Amicidin-β Solution and Amicidin-β/EF (see Pipeline).

A single Amicidin can yield multiple products

Manufacturing by
robust polymer methods

Amicrobe's synthetic biologics are manufactured by robust polymer methods (similar to those used for non-biological polymers like nylon). Kilogram scale production under GMP guidelines has been achieved. This technology and approach should allow cost-effective manufacturing through commercial production at metric ton scale. 

Amicrobe pledges its commitment to the highest standards of science, medicine, and business